A parallel group randomised open blinded evaluation of Acceptance and Commitment Therapy for depression after psychosis: Pilot trial outcomes (ADAPT)


Gumley, Andrew, White, Ross ORCID: 0000-0003-4026-6439, Briggs, Andy, Ford, Ian, Barry, Sarah, Stewart, Corinna, Beedie, Sara, McTaggart, Jacqueline, Clarke, Caoimhe, MacLeod, Rachel et al (show 4 more authors) (2017) A parallel group randomised open blinded evaluation of Acceptance and Commitment Therapy for depression after psychosis: Pilot trial outcomes (ADAPT). SCHIZOPHRENIA RESEARCH, 183. pp. 143-150.

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Abstract

<h4>Background</h4>Depression is one of the major contributors to poorer quality of life amongst individuals with psychosis and schizophrenia. The study was designed as a Pilot Trial to determine the parameters of a larger, definitive pragmatic multi-centre randomised controlled trial of Acceptance and Commitment Therapy for depression after psychosis (ACTdp) for individuals with a diagnosis of schizophrenia who also meet diagnostic criteria for major depression.<h4>Methods</h4>Participants were required to meet criteria for schizophrenia and major depression. Blinded follow-ups were undertaken at 5-months (end of treatment) and at 10-months (5-months posttreatment). Primary outcomes were depression as measured by the Calgary Depression Scale for Schizophrenia (CDSS) and the Beck Depression Inventory (BDI).<h4>Results</h4>A total of 29 participants were randomised to ACTdp + Standard Care (SC) (n=15) or SC alone (n=14). We did not observe significant differences between groups on the CDSS total score at 5-months (Coeff=-1.43, 95%CI -5.17, 2.32, p=0.45) or at 10-months (Coeff=1.8, 95%CI -2.10, 5.69, p=0.36). In terms of BDI, we noted a statistically significant effect in favour of ACTdp+SC at 5-months (Coeff=-8.38, 95%CI -15.49, -1.27, p=0.02) but not at 10-months (Coeff=-4.85, 95%CI -12.10, 2.39, p=0.18). We also observed significant effects on psychological flexibility at 5-months (Coeff=-8.83, 95%CI -14.94, -2.71, p<0.01) but not 10-months (Coeff=-4.92, 95%CI -11.09, 1.25, p=0.11).<h4>Implications</h4>In this first RCT of a psychological therapy with depression as the primary outcome, ACT is a promising intervention for depression in the context of psychosis. A further large-scale definitive randomised controlled trial is required to determine effectiveness.<h4>Trial registration</h4>ISRCTN: 33306437.

Item Type: Article
Uncontrolled Keywords: Schizophrenia, Depression, Randomised controlled trial, Pilot, Acceptance and Commitment Therapy
Depositing User: Symplectic Admin
Date Deposited: 20 Nov 2017 08:46
Last Modified: 09 Mar 2023 05:23
DOI: 10.1016/j.schres.2016.11.026
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3012446
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