Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis



Manolio, Teri A, Hutter, Carolyn M, Avigan, Mark, Cibotti, Ricardo, Davis, Robert L, Denny, Joshua C, La Grenade, Lois, Wheatley, Lisa M, Carrington, Mary N, Chantratita, Wasun
et al (show 20 more authors) (2018) Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103 (3). pp. 390-394.

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Abstract

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.

Item Type: Article
Uncontrolled Keywords: Humans, Stevens-Johnson Syndrome, Genetic Predisposition to Disease, Necrosis, Incidence, Predictive Value of Tests, Genetic Testing
Depositing User: Symplectic Admin
Date Deposited: 23 Nov 2017 10:59
Last Modified: 19 Jan 2023 06:50
DOI: 10.1002/cpt.890
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3012632