Validation of serological models for staging and prognostication of HCC in patients from a Japanese nationwide survey



Toyoda, Hienori, Tada, Toshifumi, Johnson, Philip J ORCID: 0000-0003-1404-0209, Izumi, Namiki, Kadoya, Masumi, Kaneko, Shuichi, Kokudo, Norihiro, Ku, Yonson, Kubo, Shoji, Kumada, Takashi
et al (show 5 more authors) (2017) Validation of serological models for staging and prognostication of HCC in patients from a Japanese nationwide survey. JOURNAL OF GASTROENTEROLOGY, 52 (10). pp. 1112-1121.

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Abstract

<h4>Background</h4>Two serology-based scoring models for prognostication of patients with hepatocellular carcinoma (HCC), the BALAD and BALAD-2 models, were applied to a Japanese cohort of a nationwide follow-up survey of HCC. The ability of these models to predict the progression of HCC and the deterioration of liver function and to assess prognosis was evaluated.<h4>Methods</h4>BALAD and BALAD-2 scores were calculated in 24,029 patients from a cohort of Japanese nationwide survey based on the serum levels of five markers (bilirubin, albumin, lens culinaris agglutinin-reactive alpha-fetoprotein, alpha-fetoprotein, and des-gamma-carboxy prothrombin) measured at the time of HCC diagnosis. The associations of these scores with the progression of HCC and liver function and with survival rates were analyzed.<h4>Results</h4>There were good correlations between BALAD and BALAD-2 scores and the progression of HCC and Child-Pugh class. Both scores accurately categorized patients into risk groups with different survival rates. BALAD-2 showed superior discrimination of patient survival compared with the original BALAD.<h4>Conclusions</h4>Serology-based scoring models for prognostication, especially the BALAD-2 model, were useful for staging and prognostication of survival in a cohort of Japanese patients with HCC from a nationwide survey.

Item Type: Article
Uncontrolled Keywords: Hepatocellular carcinoma, Staging, Serological markers, Tumor progression, Liver function, Prognosis
Depositing User: Symplectic Admin
Date Deposited: 15 Jan 2018 15:53
Last Modified: 19 Jan 2023 06:44
DOI: 10.1007/s00535-017-1321-6
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3016138