Steba, Gaby S, Koekkoek, Sylvie M, Vanhommerig, Joost W, Brinkman, Kees, Kwa, David, Van Der Meer, Jan TM, Prins, Maria, Berkhout, Ben, Tanck, Michael, Paxton, William A ORCID: 0000-0001-5200-0801 et al (show 3 more authors)
(2018)
DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users.
The Journal of Infectious Diseases, 217 (3).
pp. 353-357.
Text
Steba et.al. repository.pdf - Author Accepted Manuscript Download (690kB) |
Abstract
We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with HCV susceptibility. An MSM and an IDU cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN SNPs -139, -871 and -939 correlate with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlate with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.
Item Type: | Article |
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Uncontrolled Keywords: | Hepatitis C virus, Lectin, DC-SIGN, Single nucleotide polymorphism, sexual transmission |
Depositing User: | Symplectic Admin |
Date Deposited: | 19 Jan 2018 11:06 |
Last Modified: | 19 Jan 2023 06:43 |
DOI: | 10.1093/infdis/jix587 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3016391 |