TCRαβ<SUP>+</SUP>CD3<SUP>+</SUP>CD4<SUP>-</SUP>CD8<SUP>-</SUP> (double negative) T cells in autoimmunity

Brandt, D and Hedrich, CM ORCID: 0000-0002-1295-6179 (2018) TCRαβ<SUP>+</SUP>CD3<SUP>+</SUP>CD4<SUP>-</SUP>CD8<SUP>-</SUP> (double negative) T cells in autoimmunity. AUTOIMMUNITY REVIEWS, 17 (4). pp. 422-430.

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Abstract

TCRαβ⁺CD3⁺CD4^-CD8^- "double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and discussed controversially. While DN T cells resemble a rare and heterogeneous T cell subpopulation in healthy individuals, numbers of TCRαβ⁺ DN T cells are expanded in several inflammatory conditions, where they also exhibit distinct effector phenotypes and infiltrate inflamed tissues. Thus, DN T cells may be involved in systemic inflammation and tissue damage in autoimmune/inflammatory conditions, including SLE, Sjögren's syndrome, and psoriasis. Here, the current understanding of the origin and phenotype of DN T cells, and their role in the instruction of immune responses, autoimmunity and inflammation will be discussed in health and disease.

Item Type:	Article
Uncontrolled Keywords:	Double negative T cells, DN T cells, Effector T cells, SLE, Psoriasis, Inflammation
Depositing User:	Symplectic Admin
Date Deposited:	23 Feb 2018 12:21
Last Modified:	13 Oct 2023 18:11
DOI:	10.1016/j.autrev.2018.02.001
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3018359