Pseudophakic cystoid macular edema and spectral-domain optical coherence tomography-detectable central macular thickness changes with perioperative prostaglandin analogs



Walkden, Andrew, Porter, Louise F ORCID: 0000-0002-7406-0319, Morarji, Jiten, Kelly, Simon P and Sioras, Evangelos
(2017) Pseudophakic cystoid macular edema and spectral-domain optical coherence tomography-detectable central macular thickness changes with perioperative prostaglandin analogs. JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 43 (8). pp. 1027-1030.

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Abstract

<h4>Purpose</h4>To define the incidence of cystoid macular edema (CME) and spectral-domain optical coherence tomography-detectable (SD-OCT) subclinical changes in central retinal thickness in patients using prostaglandin analog (PGA) eyedrops after phacoemulsification.<h4>Setting</h4>Royal Bolton Hospital, Bolton, United Kingdom.<h4>Design</h4>Prospective case series.<h4>Methods</h4>A consecutive analysis of the incidence of postoperative CME after phacoemulsification by a single surgeon was performed in eyes of patients using PGA eyedrops between March 2010 and January 2014. The presence of CME was determined using SD-OCT (Cirrus) 3 weeks and 6 weeks postoperatively. Exclusion criteria included preexisting pathology known to predispose to CME and previous ophthalmic surgery. The paired Wilcoxon signed-rank test was used to compare central retinal thickness measurements at baseline and 3 weeks and 6 weeks postoperatively.<h4>Results</h4>All 48 patients (mean age 78.4 years; 60 eyes) had uneventful surgery. There were no cases of clinically significant CME. Subclinical CME detected by SD-OCT was confirmed in 2 eyes of different patients (3.3% of eyes), 1 eye 3 weeks postoperatively and another eye at 6 weeks. Subclinical CME resolved in both cases within 8 weeks. In both cases, the difference in central retinal thickness at baseline and 6 weeks postoperatively was statistically significant (P < .05).<h4>Conclusions</h4>The incidence of subclinical CME detectable on SD-OCT after routine phacoemulsification in patients using PGA eyedrops throughout the perioperative period was 3.3%. There were no cases of clinical CME. These findings might guide clinicians in their decision to use PGAs perioperatively.

Item Type: Article
Uncontrolled Keywords: Retina, Humans, Prostaglandins, Synthetic, Ophthalmic Solutions, Tomography, Optical Coherence, Cataract Extraction, Phacoemulsification, Prospective Studies, Macular Edema
Depositing User: Symplectic Admin
Date Deposited: 22 Jan 2019 08:21
Last Modified: 19 Jan 2023 06:38
DOI: 10.1016/j.jcrs.2017.05.029
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3019355