The Modified Ketogenic Diet in Adults with Glioblastoma: An Evaluation of Feasibility and Deliverability within the National Health Service



Martin-McGill, Kirsty J ORCID: 0000-0002-5138-2497, Marson, Anthony G ORCID: 0000-0002-6861-8806, Smith, Catrin Tudur and Jenkinson, Michael D ORCID: 0000-0003-4587-2139
(2018) The Modified Ketogenic Diet in Adults with Glioblastoma: An Evaluation of Feasibility and Deliverability within the National Health Service. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 70 (4). pp. 643-649.

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Abstract

There is an increasing interest in the use of the ketogenic diet (KD) as an adjuvant therapy for glioma patients. We assessed the tolerability and feasibility of a modified ketogenic diet (MKD) in patients with glioma, along with willingness of patients to participate in future randomized controlled trials. The study was undertaken in two parts; a patient questionnaire and evaluation of the diet. One hundred and seventy-two questionnaires were completed; 69% (n = 119) of the population reported MKD should be offered to patients with glioma and 73% (n = 125) would be willing to try MKD for 3 months. Six male patients with high grade gliomas tried the diet; 4 completed the 3-month feasibility period. Ketosis was achieved in all patients. The only gastrointestinal side effect was constipation (n = 2). Minimal changes were observed in weight, body mass index, fat mass and cholesterol profiles. MKD was well tolerated, with few side effects and is deliverable within a financially viable, NHS service. There is a high level of interest in the diet within the glioma patient community to ensure adequate recruitment for a clinical trial. Further studies are required to demonstrate efficacy and patient benefit before implementing a service.

Item Type: Article
Uncontrolled Keywords: Humans, Glioblastoma, Brain Neoplasms, Ketosis, Feasibility Studies, Adolescent, Adult, Aged, Middle Aged, Patient Participation, Costs and Cost Analysis, Female, Male, Randomized Controlled Trials as Topic, Surveys and Questionnaires, Diet, Ketogenic
Depositing User: Symplectic Admin
Date Deposited: 19 Apr 2018 07:53
Last Modified: 19 Jan 2023 06:35
DOI: 10.1080/01635581.2018.1460677
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3020356