Determining optimal therapy of dogs with chronic enteropathy by measurement of serum citrulline

Gerou-Ferriani, Magda, Allen, Rhiannon, Noble, Peter-John M, German, Alexander J ORCID: 0000-0002-3017-7988, Caldin, Marco and Batchelor, Daniel J ORCID: 0000-0003-0141-9711 (2018) Determining optimal therapy of dogs with chronic enteropathy by measurement of serum citrulline. JOURNAL OF VETERINARY INTERNAL MEDICINE, 32 (3). pp. 993-998.

Text Gerou-Ferriani_et_al-2017-Journal_of_Veterinary_Internal_Medicine.pdf - Published version Download (678kB)

Abstract

<h4>Background</h4>Serum concentration of citrulline is a useful biomarker in human intestinal disease and indicates globally reduced enterocyte mass and absorptive function in various disease states.<h4>Objectives</h4>To determine whether serum citrulline concentration is a biomarker in chronic enteropathy (CE) in dogs, to provide useful information regarding optimal treatment or to predict outcome.<h4>Animals</h4>Seventy-four dogs with CE and 83 breed- and age-matched hospital controls with no clinical signs of intestinal disease.<h4>Methods</h4>Retrospective study. Outcome was determined and dogs were categorized by response to treatment as having food-responsive enteropathy (FRE), antibiotic-responsive diarrhea (ARD), or idiopathic inflammatory bowel disease (IBD). Disease severity was quantified by the CIBDAI scoring index.<h4>Results</h4>Serum citrulline concentration did not differ between dogs with CE (median, 8.4 µg/mL, 5th-95th percentile 2.0-19.6) and controls (median, 8.1 µg/mL, 5th-95th percentile 2.2-19.7, P = .91). Serum citrulline concentration was similar between dogs with FRE (median, 9.1 µg/mL, 5th-95th percentile 2.0-18.9), ARD (median, 13.0 µg/mL, 5th-95th percentile 1.6-19.2), IBD (median, 8.4 µg/mL, 5th-95th percentile 2.1-21.0; P = .91). Serum citrulline did not correlate to CIBDAI or to serum albumin concentration.<h4>Conclusions and clinical importance</h4>In our study, serum citrulline concentration was not associated with efficacy of treatment or outcome in dogs with CE.

Item Type:	Article
Uncontrolled Keywords:	biomarker, diarrhea, IBD
Depositing User:	Symplectic Admin
Date Deposited:	23 Apr 2018 09:02
Last Modified:	19 Jan 2023 06:35
DOI:	10.1111/jvim.15124
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3020514