Decoding resistant hypertension signalling pathways

Parreira, Ricardo Cambraia, Guimaraes Lacerda, Leandro Heleno, Vasconcellos, Rebecca, Lima, Swiany Silveira, Santos, Anderson Kenedy, Fontana, Vanessa ORCID: 0000-0002-0146-9113, Sandrim, Valeria Cristina and Resende, Rodrigo Ribeiro (2017) Decoding resistant hypertension signalling pathways. CLINICAL SCIENCE, 131 (23). pp. 2813-2834.

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Abstract

Resistant hypertension (RH) is a clinical condition in which the hypertensive patient has become resistant to drug therapy and is often associated with increased cardiovascular morbidity and mortality. Several signalling pathways have been studied and related to the development and progression of RH: modulation of sympathetic activity by leptin and aldosterone, primary aldosteronism, arterial stiffness, endothelial dysfunction and variations in the renin–angiotensin–aldosterone system (RAAS). miRNAs comprise a family of small non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. miRNAs are involved in the development of both cardiovascular damage and hypertension. Little is known of the molecular mechanisms that lead to development and progression of this condition. This review aims to cover the potential roles of miRNAs in the mechanisms associated with the development and consequences of RH, and explore the current state of the art of diagnostic and therapeutic tools based on miRNA approaches.

Item Type:	Article
Uncontrolled Keywords:	microRNA, resistant hypertension, Signaling Pathways
Depositing User:	Symplectic Admin
Date Deposited:	23 Aug 2018 09:45
Last Modified:	19 Jan 2023 01:26
DOI:	10.1042/CS20171398
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3025447