Jochems, Simon P, Marcon, Fernando, Carniel, Beatriz F, Holloway, Mark, Mitsi, Elena, Smith, Emma, Gritzfeld, Jenna F, Solorzano, Carla, Reine, Jesus, Pojar, Sherin et al (show 14 more authors)
(2018)
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
NATURE IMMUNOLOGY, 19 (12).
1299-+.
Abstract
Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus during colonization are well studied in mice but remain unclear in humans. Loss of this control of pneumococcus following infection with influenza virus is associated with secondary bacterial pneumonia. We used a human challenge model with type 6B pneumococcus to show that acquisition of pneumococcus induced early degranulation of resident neutrophils and recruitment of monocytes to the nose. Monocyte function was associated with the clearance of pneumococcus. Prior nasal infection with live attenuated influenza virus induced inflammation, impaired innate immune function and altered genome-wide nasal gene responses to the carriage of pneumococcus. Levels of the cytokine CXCL10, promoted by viral infection, at the time pneumococcus was encountered were positively associated with bacterial load.
Item Type: | Article |
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Uncontrolled Keywords: | Nasal Mucosa, Neutrophils, Monocytes, Humans, Streptococcus pneumoniae, Pneumococcal Infections, Inflammation, Double-Blind Method, Chemotaxis, Leukocyte, Influenza, Human, Chemokine CXCL10, Immunity, Innate, Coinfection |
Depositing User: | Symplectic Admin |
Date Deposited: | 27 Aug 2019 10:15 |
Last Modified: | 19 Jan 2023 01:10 |
DOI: | 10.1038/s41590-018-0231-y |
Open Access URL: | https://europepmc.org/abstract/MED/30374129 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3029418 |