Working together to deliver stratified medicine research effectively



Attar, SG, Poustie, VJ, Hawcutt, DB ORCID: 0000-0002-8120-6507, Oni, L ORCID: 0000-0002-1532-2390, Beresford, MW ORCID: 0000-0002-5400-9911 and Pirmohamed, M ORCID: 0000-0002-7534-7266
(2019) Working together to deliver stratified medicine research effectively. British Medical Bulletin, 129 (1). pp. 107-116.

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Abstract

<h4>Introduction or background</h4>Stratified medicine is an important area of research across all clinical specialties, with far reaching impact in many spheres. Despite recently formulated global policy and research programmes, major challenges for delivering stratified medicine studies persist. Across the globe, clinical research infrastructures have been setup to facilitate high quality clinical research.<h4>Sources of data</h4>This article reviews the literature and summarizes views collated from a workshop held by the UK Pharmacogenetics and Stratified Medicine Network and the NIHR Clinical Research Network in November 2016.<h4>Areas of agreement</h4>Stratified medicine is an important area of clinical research and health policy, benefitting from substantial international, cross-sector investment and has the potential to transform patient care. However there are significant challenges to the delivery of stratified medicine studies.<h4>Areas of controversy</h4>Complex methodology and lack of consistency of definition and agreement on key approaches to the design, regulation and delivery of research contribute to these challenges and would benefit from greater focus.<h4>Growing points</h4>Effective partnership and development of consistent approaches to the key factors relating to stratified medicine research is required to help overcome these challenges.<h4>Areas timely for developing research</h4>This paper examines the critical contribution clinical research networks can make to the delivery of national (and international) initiatives in the field of stratified medicine. Importantly, it examines the position of clinical research in stratified medicine at a time when pressures on the clinical and social services are mounting.

Item Type: Article
Uncontrolled Keywords: stratified medicine, personalized medicine, precision medicine, clinical research networks
Depositing User: Symplectic Admin
Date Deposited: 28 Feb 2019 10:10
Last Modified: 19 Jan 2023 01:03
DOI: 10.1093/bmb/ldz003
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3032740