Ang, Li Wei, Kam, Yiu Wing, Lin, Cui, Krishnan, Prabha Unny, Tay, Joanne, Ng, Lee Ching, James, Lyn, Lee, Vernon JM, Goh, Kee Tai, Ng, Lisa FP 
ORCID: 0000-0003-4071-5222 et al (show 1 more authors)
(2017)
Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population.
PLOS NEGLECTED TROPICAL DISEASES, 11 (12).
e0006163-.
Abstract
<h4>Objectives</h4>We determined the seroprevalence of chikungunya virus (CHIKV) infection in the adult resident population in Singapore following local outbreaks of chikungunya fever (CHIKF) in 2008-2009.<h4>Methods</h4>Our cross-sectional study involved residual sera from 3,293 adults aged 18-79 years who had participated in the National Health Survey in 2010. Sera were tested for IgG antibodies against CHIKV and dengue virus (DENV) and neutralizing antibodies against CHIKV.<h4>Results</h4>The prevalence of CHIKV-neutralizing antibodies among Singapore residents aged 18-79 years was 1.9% (95% confidence interval: 1.4%- 2.3%). The CHIKV seroprevalence was highest in the elderly aged 70-79 years at 11.5%, followed by those aged 30-39 years at 3.1%. Men had significantly higher CHIKV seroprevalence than women (2.5% versus 1.3%, p = 0.01). Among the three main ethnic groups, Indians had the highest seroprevalence (3.5%) compared to Chinese (1.6%) and Malays (0.7%) (p = 0.02 and p = 0.01, respectively). Multivariable logistic regression identified adults aged 30-39 years and 70-79 years, men, those of Indian ethnicity and ethnic minority groups, and residence on ground floor of public and private housing apartments as factors that were significantly associated with a higher likelihood of exposure to CHIKV. The overall prevalence of anti-DENV IgG antibodies was 56.8% (95% CI: 55.1%- 58.5%), while 1.5% (95% CI: 1.1%- 2.0%) of adults possessed both neutralizing antibodies against CHIKV and IgG antibodies against DENV.<h4>Conclusions</h4>Singapore remains highly susceptible to CHIKV infection. There is a need to maintain a high degree of vigilance through disease surveillance and vector control. Findings from such serological study, when conducted on a regular periodic basis, could supplement surveillance to provide insights on CHIKV circulation in at-risk population.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Dengue Virus, Chikungunya virus, Antibodies, Viral, Risk Factors, Cross-Sectional Studies, Seroepidemiologic Studies, Disease Outbreaks, Adolescent, Adult, Aged, Middle Aged, Singapore, Female, Male, Young Adult, Antibodies, Neutralizing, Chikungunya Fever |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Feb 2019 10:22 |
| Last Modified: | 19 Jan 2023 01:03 |
| DOI: | 10.1371/journal.pntd.0006163 |
| Open Access URL: | http://doi.org/10.1371/journal.pntd.0006163 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3032834 |
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