Improved Exercise-Related Skeletal Muscle Oxygen Consumption Following Uptake of Endurance Training Measured Using Near-Infrared Spectroscopy



Jones, Siana, D'Silva, Andrew, Bhuva, Anish, Lloyd, Guy, Manisty, Charlotte, Moon, James C, Sharma, Sanjay and Hughes, Alun D ORCID: 0000-0001-5432-5271
(2017) Improved Exercise-Related Skeletal Muscle Oxygen Consumption Following Uptake of Endurance Training Measured Using Near-Infrared Spectroscopy. FRONTIERS IN PHYSIOLOGY, 8 (DEC). 1018-.

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Abstract

Skeletal muscle metabolic function is known to respond positively to exercise interventions. Developing non-invasive techniques that quantify metabolic adaptations and identifying interventions that impart successful response are ongoing challenges for research. Healthy non-athletic adults (18-35 years old) were enrolled in a study investigating physiological adaptations to a minimum of 16 weeks endurance training prior to undertaking their first marathon. Before beginning training, participants underwent measurements of skeletal muscle oxygen consumption using near-infrared spectroscopy (NIRS) at rest (resting muscle[Formula: see text]O<sub>2</sub>) and immediately following a maximal exercise test (post-exercise muscle[Formula: see text]O<sub>2</sub>). Exercise-related increase in muscle[Formula: see text]O<sub>2</sub> (Δm[Formula: see text]O<sub>2</sub>) was derived from these measurements and cardio-pulmonary peak[Formula: see text]O<sub>2</sub> measured by analysis of expired gases. All measurements were repeated within 3 weeks of participants completing following the marathon and marathon completion time recorded. Muscle[Formula: see text]O<sub>2</sub> was positively correlated with cardio-pulmonary peak[Formula: see text]O<sub>2</sub> (<i>r</i> = 0.63, <i>p</i> < 0.001). Muscle[Formula: see text]O<sub>2</sub> increased at follow-up (48% increase; <i>p</i> = 0.004) despite no change in cardio-pulmonary peak[Formula: see text]O<sub>2</sub> (0% change; <i>p</i> = 0.97). Faster marathon completion time correlated with higher cardio-pulmonary peak[Formula: see text]O<sub>2</sub> (<i>r</i><sub>partial</sub> = -0.58, <i>p</i> = 0.002) but not muscle[Formula: see text]O<sub>2</sub> (<i>r</i><sub>partial</sub> = 0.16, <i>p</i> = 0.44) after adjustment for age and sex [and adipose tissue thickness (ATT) for muscle[Formula: see text]O<sub>2</sub> measurements]. Skeletal muscle metabolic adaptions occur following training and completion of a first-time marathon; these can be identified non-invasively using NIRS. Although the cardio-pulmonary system is limiting for running performance, skeletal muscle changes can be detected despite minimal improvement in cardio-pulmonary function.

Item Type: Article
Uncontrolled Keywords: endurance exercise, oxygen consumption, NIRS, skeletal muscle, (V) over dot O-2 kinetics
Depositing User: Symplectic Admin
Date Deposited: 15 Feb 2019 15:32
Last Modified: 19 Jan 2023 01:03
DOI: 10.3389/fphys.2017.01018
Open Access URL: https://doi.org/10.3389/fphys.2017.01018
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3032925