Bousfield, Rachel, Thyl, Miliya, Samol, Orng, Rithea, Loet, Sona, Soeng, Chhat, Hor Put, Poda, Sar, Moore, Cartin E, Chheng, Kheng, Kumar, Varun et al (show 2 more authors)
(2016)
A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever.
PAEDIATRICS AND INTERNATIONAL CHILD HEALTH, 36 (2).
pp. 118-121.
Text
culture_negative_typhoid_study_7.12.14_final.doc - Author Accepted Manuscript Download (87kB) |
Abstract
<h4>Background</h4>Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%.<h4>Aims</h4>To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.<h4>Methods</h4>In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.<h4>Results</h4>In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.<h4>Conclusions</h4>Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.
Item Type: | Article |
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Uncontrolled Keywords: | Enteric fever, Typhoid, Cambodia, Children, Blood culture, Salmonella, Paediatric, Angkor Hospital for Children |
Depositing User: | Symplectic Admin |
Date Deposited: | 08 Apr 2019 11:06 |
Last Modified: | 31 Jan 2023 08:32 |
DOI: | 10.1179/2046905515Y.0000000009 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3036033 |