Antimicrobial susceptibility of uropathogens isolated from Cambodian children



Moore, Catrin E, Sona, Soeng, Poda, Sar, Putchhat, Hor, Kumar, Varun, Sopheary, Sun, Stoesser, Nicole, Bousfield, Rachel, Day, Nicholas and Parry, Christopher M ORCID: 0000-0001-7563-7282
(2016) Antimicrobial susceptibility of uropathogens isolated from Cambodian children. PAEDIATRICS AND INTERNATIONAL CHILD HEALTH, 36 (2). pp. 113-117.

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Abstract

<h4>Background</h4>Bacterial resistance to commonly used antimicrobials is an increasing problem in Asia but information concerning the antimicrobial susceptibility of bacteria causing urinary tract infections (UTIs) in children is limited.<h4>Methods</h4>This was a 5-year retrospective study of children with suspected UTI attending a paediatric hospital in north-west Cambodia. Urines with a positive culture containing a single organism with a count of >10(5) colony-forming units (CFU)/ml were considered diagnostic of infection. The organism was identified and the resistance pattern (using CLSI guidelines) and presence of an extended-spectrum β-lactamase (ESBL) phenotype was determined.<h4>Results</h4>In total, there were 217 episodes of infection, 210 (97%) with Gram-negative bacteria. Escherichia coli was the most common infecting isolate with high levels of resistance to most oral antibiotics, except nitrofurantoin. Nearly half of the E. coli (44%) were extended-spectrum cephalosporin (ESC)-resistant with the proportion increasing significantly over the 5-year period. ESC-resistant E. coli were more likely to be multi-drug-resistant and 91% demonstrated an ESBL phenotype.<h4>Conclusion</h4>The data highlight the importance of microbiological surveillance of UTIs in children, particularly in areas where there are known to be multiply resistant organisms.

Item Type: Article
Uncontrolled Keywords: Urinary tract infection, Cambodia, Children, Escherichia coli, ESBL, Resistance
Depositing User: Symplectic Admin
Date Deposited: 13 May 2019 08:48
Last Modified: 31 Jan 2023 08:32
DOI: 10.1179/2046905515Y.0000000008
Open Access URL: https://doi.org/10.1177/2325967118818064
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3040992