IP-10 Kinetics in the First Week of Therapy are Strongly Associated with Bacteriological Confirmation of Tuberculosis Diagnosis in HIV-Infected Patients


Garcia-Basteiro, Alberto L, Mambuque, Edson, den Hertog, Alice, Saavedra, Belen, Cuamba, Inocencia, Oliveras, Laura, Blanco, Silvia, Bulo, Helder, Brew, Joe, Cuevas, Luis E ORCID: 0000-0002-6581-0587 et al (show 3 more authors) (2017) IP-10 Kinetics in the First Week of Therapy are Strongly Associated with Bacteriological Confirmation of Tuberculosis Diagnosis in HIV-Infected Patients. SCIENTIFIC REPORTS, 7 (1). 14302-.

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Abstract

Simple effective tools to monitor the long treatment of tuberculosis (TB) are lacking. Easily measured host derived biomarkers have been identified but need to be validated in larger studies and different population groups. Here we investigate the early response in IP-10 levels (between day 0 and day 7 of TB therapy) to identify bacteriological status at diagnosis among 127 HIV-infected patients starting TB treatment. All participants were then classified as responding or not responding to treatment blindly using a previously described IP-10 kinetic algorithm. There were 77 bacteriologically confirmed cases and 41 Xpert MTB/RIF® and culture negative cases. Most participants had a measurable decline in IP-10 during the first 7 days of therapy. Bacteriologically confirmed cases were more likely to have high IP-10 levels at D0 and had a steeper decline than clinically diagnosed cases (mean decline difference 2231 pg/dl, 95% CI: 897-3566, p = 0.0013). Bacteriologically confirmed cases were more likely to have a measurable decline in IP-10 at day 7 than clinically diagnosed cases (48/77 (62.3%) vs 13/41 (31.7%), p < 0.001). This study confirms the association between a decrease in IP-10 levels during the first week of treatment and a bacteriological confirmation at diagnosis in a large cohort of HIV positive patients.

Item Type: Article
Uncontrolled Keywords: Humans, Mycobacterium tuberculosis, Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary, HIV Infections, HIV Seropositivity, Antibiotics, Antitubercular, Treatment Outcome, Microbial Sensitivity Tests, Drug Resistance, Bacterial, Algorithms, Adolescent, Adult, Middle Aged, Female, Male, Chemokine CXCL10, Young Adult, Surveys and Questionnaires
Depositing User: Symplectic Admin
Date Deposited: 15 May 2019 10:14
Last Modified: 19 Jan 2023 00:45
DOI: 10.1038/s41598-017-13785-3
Open Access URL: http://doi.org/10.1038/s41598-017-13785-3
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3041436
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