The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash.

Sharma, Amy, Saito, Yoshiro, Hung, Shuen-Iu, Naisbitt, Dean, Uetrecht, Jack and Bussiere, Jeanine (2018) The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash. Journal of immunotoxicology, 16 (1). pp. 1-12.

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Official URL: http://dx.doi.org/10.1080/1547691x.2018.1514444

Abstract

Current advances in the study of cutaneous adverse drug reactions can be attributed to the recent understanding that the skin is both a metabolically and immunologically competent organ. The ability of the skin to serve as a protective barrier with limited drug biotransformation ability, yet highly active immune function, has provided insights into its biological capability. While the immune response of the skin to drugs is vastly different from that of the liver due to evolutionary conditioning, it frequently occurs in response to various drug classes and manifests as a spectrum of hypersensitivity reactions. The skin is a common site of adverse and idiosyncratic drug reactions; drug-specific T-cells, as well as involvement of an innate immune response, appear to be key mechanistic drivers in such scenarios. Association of other factors such as human leukocyte antigen (HLA) polymorphisms may play a significant role for particular drugs. This review aims to integrate emerging findings into proposed mechanisms of drug metabolism and immunity in the skin that are likely responsible for rashes and other local allergic responses. These unique biological aspects of the skin, and their translation into implications for drug development and the use of animal models, will be discussed.

Item Type:	Article
Uncontrolled Keywords:	Skin toxicology, idiosyncratic, pharmacogenomics, mechanisms, metabolism, skin rash bioactivation, adverse drug reaction, immunology
Depositing User:	Symplectic Admin
Date Deposited:	05 Jun 2019 09:17
Last Modified:	19 Jan 2023 00:41
DOI:	10.1080/1547691x.2018.1514444
Open Access URL:	https://doi.org/10.1080/1547691X.2018.1514444
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3044541