Clare, Daniel, Dobson, Benjamin C, Inglesby, Phillip A and Aïssa, Christophe 
ORCID: 0000-0003-0750-9435
(2019)
Chemospecific Cyclizations of α‐Carbonyl Sulfoxonium Ylides on Aryls and Heteroaryls.
Angewandte Chemie, 131 (45).
pp. 16344-16348.
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Abstract
<jats:title>Abstract</jats:title><jats:p>The functionalization of aryl and heteroaryls using α‐carbonyl sulfoxonium ylides without the help of a directing group has remained so far a neglected area, despite the advantageous safety profile of sulfoxonium ylides. Described herein are the cyclizations of α‐carbonyl sulfoxonium ylides onto benzenes, benzofurans and <jats:italic>N</jats:italic>‐<jats:italic>p</jats:italic>‐toluenesulfonyl indoles in the presence of a base in HFIP, whereas pyrroles and <jats:italic>N</jats:italic>‐methyl indoles undergo cyclization in the presence of an iridium catalyst. Significantly, these two sets of conditions are chemospecific for each groups of substrates.</jats:p>
| Item Type: | Article |
|---|---|
| Depositing User: | Symplectic Admin |
| Date Deposited: | 19 Nov 2019 17:06 |
| Last Modified: | 18 Sep 2023 18:00 |
| DOI: | 10.1002/ange.201910821 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3062445 |
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