Molecular pathogenesis of proliferative verrucous leukoplakia: a systematic review

Okoturo, EM, Risk, JM ORCID: 0000-0002-8770-7783, Schache, AG ORCID: 0000-0001-9466-6038, Shaw, RJ ORCID: 0000-0002-5157-4042 and Boyd, MT ORCID: 0000-0002-2336-2106
(2018) Molecular pathogenesis of proliferative verrucous leukoplakia: a systematic review. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 56 (09). pp. 780-785.

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Proliferative verrucous leukoplakia (PVL) is a potentially premalignant lesion that undergoes malignant transformation in over 40% of cases. Its clinical homogeneity suggests that a single or a small number of molecular pathogenic pathways may exist. Using the Cochrane protocol for systematic reviews, we have looked at the reported evidence of the molecular aetiology and pathogenesis of PVL and compared it with that of conventional oral epithelial dysplasia (OED). Of the 43 papers studied, 19 met the inclusion criteria including 13 proteins assayed in 344 tissues, and genes investigated were TP53, p14ARF, and p16INK4A. In all studies the research objectives were defined and outcomes were clearly stated. This review has shown that the transformation of PVL does not follow the same pathway as that of OED. There was weak evidence to suggest possible correlations between DNA aneuploidy, loss of heterozygosity at locus 9p21, and specific expression of Mcm (mini chromosome maintenance) protein, to transformation of PVL. To show important or distinct pathways of this condition, further studies are needed to access the somatic genomic alterations that are found in malignancies.

Item Type: Article
Uncontrolled Keywords: Proliferative Venucous Leukoplakia, Systematic Review
Depositing User: Symplectic Admin
Date Deposited: 26 Nov 2019 10:06
Last Modified: 19 Jan 2023 00:19
DOI: 10.1016/j.bjoms.2018.08.010
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