Lum, Fok-Moon, Narang, Vipin, Hue, Susan, Chen, Jie, McGovern, Naomi, Rajarethinam, Ravisankar, Tan, Jeslin JL, Amrun, Siti Naqiah, Chan, Yi-Hao, Lee, Cheryl YP et al (show 12 more authors)
(2019)
Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.
Clinical and Translational Immunology, 8 (11).
e01082-.
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Clin Transl Immunol_Trimester specific placentas ZIKV_Lum_2019.pdf - Published version Download (3MB) | Preview |
Abstract
Objectives Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear. Methods Full‐term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis. Results In this study, each woman exhibited a unique immune response with raised IL‐1RA, IP‐10, EGF and RANTES expression and neutrophil numbers during the acute infection phase. Although ZIKV NS3 antigens co‐localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential eIF2 signalling, mitochondrial dysfunction and oxidative phosphorylation. Despite these, the babies were delivered without any congenital anomalies. Conclusion These findings should translate to improve clinical prenatal screening procedures for virus‐infected pregnant patients.
| Item Type: | Article |
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| Uncontrolled Keywords: | histology, infection, placenta, RNA-seq, transcriptomics, Zika virus |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Dec 2019 10:39 |
| Last Modified: | 19 Jan 2023 00:16 |
| DOI: | 10.1002/cti2.1082 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3064945 |
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