Preliminary investigation of serum cardiac troponin I in dogs with acute ischaemic stroke

Goncalves, R ORCID: 0000-0001-5420-9801, Sanchez-Masian, D, Maddox, TW and Dukes-McEwan, J ORCID: 0000-0002-0326-8251 (2020) Preliminary investigation of serum cardiac troponin I in dogs with acute ischaemic stroke. JOURNAL OF SMALL ANIMAL PRACTICE, 61 (2). pp. 93-100.

Text Troponin I elevation in dogs with acute ischaemic strokes - underlined correctionsv3.docx - Author Accepted Manuscript Download (63kB)

Abstract

<h4>Objectives</h4>To describe the incidence of elevated serum cardiac troponin I in dogs with acute ischaemic strokes, to evaluate its prognostic value in these patients and characterise a possible relationship between cardiac troponin I elevation in dogs with ischaemic strokes and underlying cardiac dysfunction.<h4>Materials and methods</h4>Prospective study of 18 dogs with acute ischaemic stroke diagnosed by MRI of the brain. Serum cardiac troponin I concentration, trans-thoracic echocardiography and six-lead electrocardiography were performed and findings were compared between dogs with good and poor outcome.<h4>Results</h4>Serum cardiac troponin I was increased in 17 dogs (median 0.95 ng/mL; range 0.146 to 153). Focal hyperechoic regions of myocardium were visible in two dogs using trans-thoracic echocardiography and presumed to represent acute infarcts. A significant association was found between cardiac troponin I and creatinine concentrations. No difference in cardiac troponin I concentrations was detected between dogs that experienced good and poor outcomes. Clinically important cardiac dysfunction was identified in two dogs.<h4>Clinical significance</h4>Cardiac troponin I is commonly elevated in patients diagnosed with acute ischaemic stroke but, in this small study population, did not have prognostic value. Larger studies (recruiting a study population of 98 dogs for a power of 0.8 and a 0.05 alpha/critical value) would aid in further investigation of these preliminary results.

Item Type:	Article
Uncontrolled Keywords:	Animals, Dogs, Brain Ischemia, Dog Diseases, Troponin I, Prognosis, Prospective Studies, Stroke, Biomarkers
Depositing User:	Symplectic Admin
Date Deposited:	02 Jan 2020 15:55
Last Modified:	19 Jan 2023 00:11
DOI:	10.1111/jsap.13097
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3068875