Controlled synthesis of calcium carbonate nanoparticles and stimuli-responsive multi-layered nanocapsules for oral drug delivery

Elbaz, Nancy M, Owen, Andrew ORCID: 0000-0002-9819-7651, Rannard, Steve ORCID: 0000-0002-6946-1097 and McDonald, Tom O ORCID: 0000-0002-9273-9173 (2020) Controlled synthesis of calcium carbonate nanoparticles and stimuli-responsive multi-layered nanocapsules for oral drug delivery. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 574. 118866-.

Text
International journal of pharmaceutics final with figures.docx - Author Accepted Manuscript
Download (2MB)

Official URL: http://dx.doi.org/10.1016/j.ijpharm.2019.118866

Abstract

Stimuli-responsive layer-by-layer (LbL) capsules are appealing drug carriers for oral drug delivery owing to their abilities to utilize environmental differences to trigger changes in particles properties. LbL capsules typically have micrometer diameter ranging between 1 and 5 µm. The opportunity to use LbL for the modification of particles in the nanorange may provide enhanced benefits and properties for drug delivery. In this work, we used multiple polyelectrolytes to prepare novel stimuli-responsive multi-layered nanocapsules with submicron diameters. A systematic study was conducted to investigate the influence of various experimental parameters on the formation of calcium carbonate nanoparticles (CaCO<sub>3</sub>) as nanocores. The resultant nanocores were then used for the assembly of LbL nanocapsules and the variables that influenced the diameter of capsules were investigated. Finally, novel stimuli-responsive multi-layered nanocapsules made of four polyelectrolytes including Eudragit L100, chitosan, sodium alginate, and poly-L-arginine were prepared and characterized. The stimuli-responsive multi-layered nanocapsules loaded with a model drug, curcumin, were assessed for drug release under pH conditions that mimic the gastrointestinal tract. These data demonstrate the potential for nanocapsules to be designed to protect the drug in the stomach and release it in the lower gastrointestinal tract.

Item Type:	Article
Uncontrolled Keywords:	Layer-by-Layer (LbL) self-assembly, LbL nanocapsules, Calcium carbonate nanoparticles, Curcumin, Stimuli responsive multi-layered nanocapsules
Depositing User:	Symplectic Admin
Date Deposited:	10 Feb 2020 10:32
Last Modified:	25 Jan 2024 05:53
DOI:	10.1016/j.ijpharm.2019.118866
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3073738