Muliaditan, Morris, Davies, Geraint R 
ORCID: 0000-0002-3819-490X, Simonsson, Ulrika SH, Gillespie, Stephen H and Della Pasqua, Oscar
(2017)
The implications of model-informed drug discovery and development for tuberculosis.
DRUG DISCOVERY TODAY, 22 (3).
pp. 481-486.
Abstract
Despite promising advances in the field and highly efficacious first-line treatment, an estimated 9.6 million people are still infected with tuberculosis (TB). Innovative methods are required to effectively transition the growing number of compounds into novel combination regimens. However, progression of compounds into patients occurs despite the lack of clear understanding of the pharmacokinetic-pharmacodynamic (PKPD) relationships. The PreDiCT-TB consortium was established in response to the existing gaps in TB drug development. The aim of the consortium is to develop new preclinical tools in concert with an in silico model-based approach, grounded in PKPD principles. Here, we highlight the potential impact of such an integrated framework on the various stages of TB drug development and on the dose rationale for drug combinations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Humans, Tuberculosis, Antitubercular Agents, Drug Approval, Models, Theoretical, Drug Discovery |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Feb 2020 11:32 |
| Last Modified: | 19 Jan 2023 00:04 |
| DOI: | 10.1016/j.drudis.2016.09.004 |
| Open Access URL: | https://research-repository.st-andrews.ac.uk/bitst... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3073782 |
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