Trans-ethnic association study of blood pressure determinants in over 750,000 individuals



Giri, Ayush, Hellwege, Jacklyn N, Keaton, Jacob M, Park, Jihwan, Qiu, Chengxiang, Warren, Helen R, Torstenson, Eric S, Kovesdy, Csaba P, Sun, Yan V, Wilson, Otis D
et al (show 88 more authors) (2019) Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. NATURE GENETICS, 51 (1). 51-+.

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Abstract

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.

Item Type: Article
Uncontrolled Keywords: Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Million Veteran Program, Kidney Tubules, Animals, Humans, Mice, Gene Expression, Up-Regulation, Blood Pressure, Polymorphism, Single Nucleotide, Adolescent, Middle Aged, Ethnic Groups, Female, Male, Genome-Wide Association Study, Transcriptome
Depositing User: Symplectic Admin
Date Deposited: 17 Feb 2020 09:41
Last Modified: 19 Jan 2023 00:03
DOI: 10.1038/s41588-018-0303-9
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3074703