Sudunagunta, Siddarth ORCID: 0000-0003-4781-7280, Green, Daniel, Christley, Rob ORCID: 0000-0001-9250-3032 and Dukes McEwan, J ORCID: 0000-0002-0326-8251
(2019)
The prevalence of pulmonary hypertension in Cavalier King Charles spaniels compared with other breeds with myxomatous mitral valve disease.
Journal of Veterinary Cardiology, 23.
pp. 21-31.
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Abstract
<h4>Introduction</h4>Pulmonary hypertension (PH) is a common consequence of myxomatous mitral valve disease (MMVD). Cavalier King Charles spaniels (CKCS) are frequently affected with MMVD and appear to have different disease progression compared to other dogs. This study aimed to determine if CKCS are more likely to develop PH as a result of MMVD than dogs of other breeds. A secondary aim was to explore whether breed or PH impacted survival.<h4>Animals</h4>A total of 187 dogs diagnosed with MMVD, 94 CKCS and 93 non-CKCS, were included in this study.<h4>Methods</h4>This is a retrospective review of dogs with MMVD. Data were analyzed for presence of PH, congestive heart failure (CHF) and echocardiographic variables including the ratio between mitral E wave velocity (E vel) and isovolumic relaxation time (E/IVRT) and were compared between CKCS/non-CKCS and dogs with/without PH. Survival analysis was also performed.<h4>Results</h4>American College of Veterinary Internal Medicine (ACVIM) stage (p < 0.001), CKCS (p = 0.005), left atrium-to-aortic ratio (LA/Ao) (p < 0.001), E vel (p < 0.001) and log<sub>10</sub>(E/IVRT) (p < 0.001) were significant at the univariate level for PH development. At the multivariate level, only ACVIM stage remained significant (p = 0.044), suggesting that worsening MMVD was the predominant determinant of PH development in this study. Pulmonary hypertension was associated with greater likelihood of CHF (p < 0.001) and death (both cardiac [p < 0.001] and all-cause mortality [p = 0.011]). Cavalier King Charles spaniels were more likely to experience cardiac death than non-CKCS (p = 0.004).<h4>Conclusions</h4>In this study, development of PH was associated with worse MMVD, according to ACVIM stage.
Item Type: | Article |
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Uncontrolled Keywords: | Canine, Tricuspid regurgitation, Postcapillary pulmonary hypertension, Degenerative valvular disease |
Depositing User: | Symplectic Admin |
Date Deposited: | 14 Feb 2020 10:39 |
Last Modified: | 19 Jan 2023 00:03 |
DOI: | 10.1016/j.jvc.2019.01.002 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3074990 |
Available Versions of this Item
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The prevalence of pulmonary hypertension in Cavalier King Charles spaniels compared with other breeds with myxomatous mitral valve disease. (deposited 23 Apr 2019 09:33)
- The prevalence of pulmonary hypertension in Cavalier King Charles spaniels compared with other breeds with myxomatous mitral valve disease. (deposited 14 Feb 2020 10:39) [Currently Displayed]