De Rycker, Manu, Horn, David, Aldridge, Bree, Amewu, Richard K 
ORCID: 0000-0002-4676-436X, Barry, Clifton EIII, Buckner, Frederick S, Cook, Sarah, Ferguson, Michael AJ, Gobeau, Nathalie, Herrmann, Jennifer et al (show 27 more authors)
(2020)
Setting Our Sights on Infectious Diseases.
ACS INFECTIOUS DISEASES, 6 (1).
pp. 3-13.
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Abstract
In May 2019, the Wellcome Centre for Anti-Infectives Research (<i>W</i>CAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Communicable Diseases, HIV Infections, Combined Modality Therapy, Drug Evaluation, Preclinical, Communicable Disease Control, Poverty, Congresses as Topic, Drug Discovery, United Kingdom |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Feb 2020 15:15 |
| Last Modified: | 19 Jan 2023 00:01 |
| DOI: | 10.1021/acsinfecdis.9b00371 |
| Open Access URL: | https://pubs.acs.org/doi/10.1021/acsinfecdis.9b003... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3076065 |
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