DNA Damage/Repair Management in Cancers

Alhmoud, Jehad F, Woolley, John F ORCID: 0000-0001-7885-8515, Moustafa, Ala-Eddin Al and Malki, Mohammed Imad (2020) DNA Damage/Repair Management in Cancers. Cancers, 12 (4). p. 1050.

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Official URL: http://dx.doi.org/10.3390/cancers12041050

Abstract

<jats:p>DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA damage occurs, the possibility of generated mutations increases. Genomic instability is one of the most important factors that lead to cancer development. DNA repair pathways perform the essential role of correcting the DNA lesions that occur from DNA damaging agents or carcinogens, thus maintaining genomic stability. Inefficient DNA repair is a critical driving force behind cancer establishment, progression and evolution. A thorough understanding of DNA repair mechanisms in cancer will allow for better therapeutic intervention. In this review we will discuss the relationship between DNA damage/repair mechanisms and cancer, and how we can target these pathways.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	DNA damage, DNA repair pathway, DNA lesion, genomic instability
Depositing User:	Symplectic Admin
Date Deposited:	27 Apr 2020 10:29
Last Modified:	18 Jan 2023 23:53
DOI:	10.3390/cancers12041050
Open Access URL:	https://www.mdpi.com/2072-6694/12/4/1050
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3084768