Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a

Gordon, MA ORCID: 0000-0002-0629-0884 (2019) Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. Science Advances, 5 (2). eaau6849-.

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Abstract

Epidemiological and immunological evidence suggests that some vaccines can reduce all-cause mortality through nonspecific changes made to innate immune cells. Here, we present the first data to describe the nonspecific immunological impact of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. We vaccinated healthy adults with Ty21a and assessed aspects of innate and adaptive immunity over the course of 6 months. Changes to monocyte phenotype/function were observed for at least 3 months. Changes to innate and adaptive immune cell cytokine production in response to stimulation with vaccine and unrelated nonvaccine antigens were observed over the 6-month study period. The changes that we have observed could influence susceptibility to infection through altered immune responses mounted to subsequently encountered pathogens. These changes could influence all-cause mortality.

Item Type:	Article
Uncontrolled Keywords:	CD4-Positive T-Lymphocytes, Monocytes, Humans, Salmonella typhi, Typhoid Fever, Polysaccharides, Bacterial, Typhoid-Paratyphoid Vaccines, Vaccines, Attenuated, Cytokines, Vaccination, Administration, Oral, Adult, Middle Aged, Female, Male, Young Adult, Healthy Volunteers
Depositing User:	Symplectic Admin
Date Deposited:	06 May 2020 10:02
Last Modified:	18 Jan 2023 23:53
DOI:	10.1126/sciadv.aau6849
Open Access URL:	https://doi.org/10.1126/sciadv.aau6849
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3085434

Available Versions of this Item

• Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. (deposited 01 Mar 2019 08:30)
  • Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. (deposited 06 May 2020 10:02) [Currently Displayed]