Biosimilars in pediatric rheumatology and their introduction into routine care

Cuevas, Octavio Aragon and Hedrich, Christian M ORCID: 0000-0002-1295-6179
(2020) Biosimilars in pediatric rheumatology and their introduction into routine care. Clinical Immunology, 216. 108447-.

[thumbnail of Biosimilars.pdf] Text
Biosimilars.pdf - Author Accepted Manuscript

Download (778kB) | Preview


Biosimilars are biologic medications that are slightly altered versions of already approved biologic disease modifying anti-rheumatic drugs (bDMARDs). They can be manufactured after the original product's patent protection expires. The advent of biosimilar use in pediatric rheumatology started with the biosimilar to infliximab in 2013. Since then, more biosimilars have been made available including etanercept, rituximab and adalimumab. This manuscript briefly reviews the history of biosimilar introduction to treatment and suggests strategies for the adoption of biosimilar drugs in services specialized in Pediatric Rheumatology, including potential barriers and solutions to their implementation into practice. The review covers general aspects relevant to all biosimilar drugs and specific examples covering individual drugs based on the experience of a large tertiary pediatric rheumatology service in the Northwest of England.

Item Type: Article
Uncontrolled Keywords: Biosimilar, Children, Rheumatology, Pediatrics, Treatment
Depositing User: Symplectic Admin
Date Deposited: 20 May 2020 09:18
Last Modified: 18 Jan 2023 23:51
DOI: 10.1016/j.clim.2020.108447
Related URLs: