Preciado-Llanes, Lorena, Aulicino, Anna, Canals, Rocío, Moynihan, Patrick, Zhu, Xiaojun, Jambo, Ndaru, Nyirenda, Tonney, Kadwala, Innocent, Owen, Siân V, Veerapen, Natacha et al (show 6 more authors)
(2020)
African Salmonella Typhimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB.
Proceedings of the National Academy of Sciences of USA.
762955-.
Abstract
<jats:title>SUMMARY</jats:title><jats:p>Mucosal-associated invariant T (MAIT) cells are a subset of innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defence. However, proposed protective roles of MAIT cells in human infections remain unproven and clinical conditions associated with a selective absence of MAIT cells have not been identified. We report that typhoidal and non-typhoidal <jats:italic>S. enterica</jats:italic> strains generally activate MAIT cells. However, African invasive disease-associated multidrug-resistant <jats:italic>S.</jats:italic> Typhimurium sequence type 313 lineage 2 strains escape MAIT cell recognition through overexpression of <jats:italic>ribB</jats:italic>, a bacterial gene that encodes the 4-dihydroxy-2-butanone 4-phosphate synthase enzyme of the riboflavin biosynthetic pathway. This MAIT cell-specific phenotype did not extend to other innate lymphocytes. We propose that <jats:italic>ribB</jats:italic> overexpression is an evolved trait that facilitates evasion from immune recognition by MAIT cells and contributes to the invasive pathogenesis of <jats:italic>S.</jats:italic> Typhimurium sequence type 313 lineage 2 <jats:italic>in vivo</jats:italic>.</jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | Vaccine Related, Immunization, HIV/AIDS, Prevention, Biodefense, Emerging Infectious Diseases, Infectious Diseases, 2.1 Biological and endogenous factors, 2 Aetiology, Infection |
Depositing User: | Symplectic Admin |
Date Deposited: | 07 Jul 2020 07:47 |
Last Modified: | 15 Mar 2024 02:50 |
DOI: | 10.1101/762955 |
Open Access URL: | https://doi.org/10.1073/pnas.2007472117 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3093041 |