Koks, Gea, Prans, Ele, Ho, Xuan D, Duy, Binh H, Tran, Ha DT, Ngo, Ngoc BT, Hoang, Linh NN, Tran, Hue MT, Bubb, Vivien J ORCID: 0000-0003-2763-7004, Quinn, John P ORCID: 0000-0003-3551-7803 et al (show 1 more authors)
(2020)
Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence.
EXPERIMENTAL BIOLOGY AND MEDICINE, 245 (8).
pp. 733-739.
Text
Polymorphisms in the MAOA_VN_ND_12032020_koks_REV.pdf - Author Accepted Manuscript Download (153kB) | Preview |
Abstract
<h4>Impact statement</h4>The present study combined the analysis of two transcriptional regulators, uVNTR and dVNTR, in the MAOA gene that is an enzyme responsible for the monoamine degradation and identified genetic interaction between these VNTRs in association with the nicotine dependence. The main impact is that when analyzing different populations in the genetic studies, the functionally meaningful variants should be combined rather than addressing individual elements separately (a mini polygenic risk score for a particular gene/locus). This combination is very rarely analyzed and therefore the study sets an example. Another impact is that we analyzed the genetic variability in the Asian population and therefore our data present a piece of information from underrepresented populations.
Item Type: | Article |
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Uncontrolled Keywords: | Variable number tandem repeat, MAOA, smoking, nicotine dependence, Fagerstrom Test for Nicotine Dependence, Vietnam, genetic interaction, stratification |
Depositing User: | Symplectic Admin |
Date Deposited: | 14 Sep 2020 08:15 |
Last Modified: | 15 Mar 2024 03:55 |
DOI: | 10.1177/1535370220916888 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3101018 |