Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence



Koks, Gea, Prans, Ele, Ho, Xuan D, Duy, Binh H, Tran, Ha DT, Ngo, Ngoc BT, Hoang, Linh NN, Tran, Hue MT, Bubb, Vivien J ORCID: 0000-0003-2763-7004, Quinn, John P ORCID: 0000-0003-3551-7803
et al (show 1 more authors) (2020) Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence. EXPERIMENTAL BIOLOGY AND MEDICINE, 245 (8). pp. 733-739.

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Abstract

<h4>Impact statement</h4>The present study combined the analysis of two transcriptional regulators, uVNTR and dVNTR, in the MAOA gene that is an enzyme responsible for the monoamine degradation and identified genetic interaction between these VNTRs in association with the nicotine dependence. The main impact is that when analyzing different populations in the genetic studies, the functionally meaningful variants should be combined rather than addressing individual elements separately (a mini polygenic risk score for a particular gene/locus). This combination is very rarely analyzed and therefore the study sets an example. Another impact is that we analyzed the genetic variability in the Asian population and therefore our data present a piece of information from underrepresented populations.

Item Type: Article
Uncontrolled Keywords: Variable number tandem repeat, MAOA, smoking, nicotine dependence, Fagerstrom Test for Nicotine Dependence, Vietnam, genetic interaction, stratification
Depositing User: Symplectic Admin
Date Deposited: 14 Sep 2020 08:15
Last Modified: 15 Mar 2024 03:55
DOI: 10.1177/1535370220916888
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3101018