Gupta, Ishita, Ghabreau, Lina, Al-Thawadi, Hamda, Yasmeen, Amber, Vranic, Semir, Al Moustafa, Ala-Eddin and Malki, Mohammed I
(2020)
Co-incidence of Human Papillomaviruses and Epstein–Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria.
Frontiers in Oncology, 10.
1016-.
Abstract
High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the initiation and/or progression of this cancer. Accordingly, we herein explored the prevalence of high-risk HPVs and EBV in 80 HN cancer tissues from the Syrian population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We report that high-risk HPVs and EBV are present in 35/80 (43.7%) and 41/80 (51.2%) of our samples, respectively, and the most frequent HPV types are 33, 16, 18, 45, 52, 58, 35, 51, and 31, in this order. More significantly, our data reveal that 25/80 (31.2%) of cancer cases are positive for high-risk HPVs as well as EBV, and their co-presence is associated with high/intermediate-grade squamous cell carcinomas. These data confirm the co-presence of high-risk HPVs and EBV in HN cancers in the Syrian population of the Middle East and demonstrate that their co-incidence is linked to a more aggressive cancer phenotype. Thus, future studies are required to confirm these data and elucidate the exact role of high-risk and EBV cooperation in human HN carcinogenesis.
Item Type: | Article |
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Uncontrolled Keywords: | head and neck cancers, human papillomaviruses, Epstein-Barr virus, tumor grade, Syrian population |
Depositing User: | Symplectic Admin |
Date Deposited: | 14 Sep 2020 10:47 |
Last Modified: | 18 Jan 2023 23:33 |
DOI: | 10.3389/fonc.2020.01016 |
Open Access URL: | https://www.frontiersin.org/articles/10.3389/fonc.... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3101139 |