Alternative splicing of leptin receptor overlapping transcript in osteosarcoma



Rothzerg, Emel, Ho, Xuan D, Xu, Jiake, Wood, David, Martson, Aare, Maasalu, Katre and Koks, Sulev ORCID: 0000-0001-6087-6643
(2020) Alternative splicing of leptin receptor overlapping transcript in osteosarcoma. EXPERIMENTAL BIOLOGY AND MEDICINE, 245 (16). pp. 1437-1443.

[thumbnail of AcceptedManuscriptEBM-20-RM-0540.R2_Proof_hi.pdf] Text
AcceptedManuscriptEBM-20-RM-0540.R2_Proof_hi.pdf - Author Accepted Manuscript

Download (740kB) | Preview

Abstract

<h4>Impact statement</h4>Osteosarcoma (OS, also known as osteogenic sarcoma) is the most common primary malignancy of bone in children and adolescents. The molecular mechanisms of OS are extremely complicated and its molecular mediators remain to be elucidated. We sequenced total RNA from 18 OS bone samples (paired normal-tumor biopsies). We found statistically significant (FDR <0.05) 26 differentially expressed transcript variants of <i>LEPROT</i> gene with different expressions in normal and tumor samples. These findings contribute to the understanding of molecular mechanisms of OS development and provide encouragement to pursue further research.

Item Type: Article
Uncontrolled Keywords: Osteosarcoma, transcriptome, LEPROT, RNA sequencing, alternative splicing, osteogenic sarcoma
Depositing User: Symplectic Admin
Date Deposited: 16 Sep 2020 08:55
Last Modified: 15 Mar 2024 04:39
DOI: 10.1177/1535370220949139
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3101375