Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury

Gibson, Andrew, Hammond, Sean, Jaruthamsophon, Kanoot ORCID: 0000-0003-1563-0024, Roth, Sharin, Mosedale, Merrie and Naisbitt, Dean J (2020) Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33 (11). pp. 2745-2748.

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Official URL: http://dx.doi.org/10.1021/acs.chemrestox.0c00328

Abstract

Tolvaptan is an effective drug for the treatment of autosomal dominant polycystic kidney disease, but its use is associated with a significant risk of liver injury in a small number of patients. Herein we describe the presence of tolvaptan- and tolvaptan-metabolite-responsive T cell clones within the peripheral circulation of patients with liver injury. Drug treatment of the clones resulted in a proliferative response and secretion of IFN-γ, IL-13, and the cytolytic molecule granzyme B. Future work should explore pathways of tolvaptan driven T cell activation and the role of T cells in the disease pathogenesis.

Item Type:	Article
Uncontrolled Keywords:	T-Lymphocytes, Humans, Cell Proliferation, Molecular Structure, Adult, Middle Aged, Female, Male, Chemical and Drug Induced Liver Injury, Tolvaptan
Depositing User:	Symplectic Admin
Date Deposited:	04 Nov 2020 14:49
Last Modified:	18 Jan 2023 23:23
DOI:	10.1021/acs.chemrestox.0c00328
Open Access URL:	https://doi.org/10.1021/acs.chemrestox.0c00328
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3106043