The Current Landscape of Novel Formulations and the Role of Mathematical Modeling in Their Development

Cottura, Nicolas ORCID: 0000-0003-3083-2249, Howarth, Alice ORCID: 0000-0003-2288-1745, Rajoli, Rajith KR ORCID: 0000-0002-6015-5712 and Siccardi, Marco ORCID: 0000-0002-3539-7867 (2020) The Current Landscape of Novel Formulations and the Role of Mathematical Modeling in Their Development. JOURNAL OF CLINICAL PHARMACOLOGY, 60 (S1). S77-S97.

Text jcph1715_Rev_EV.PDF - Published version Download (2MB) | Preview

Abstract

Drug delivery is an integral part of the drug development process, influencing safety and efficacy of active pharmaceutical ingredients. The application of nanotechnology has enabled the discovery of novel formulations for numerous therapeutic purposes across multiple disease areas. However, evaluation of novel formulations in clinical scenarios is slow and hampered due to various ethical and logistical barriers. Computational models have the ability to integrate existing domain knowledge and mathematical correlations, to rationalize the feasibility of using novel formulations for safely enhancing drug delivery, identifying suitable candidates, and reducing the burden on preclinical and clinical studies. In this review, types of novel formulations and their application through several routes of administration and the use of modeling approaches that can find application in different stages of the novel formulation development process are discussed.

Item Type:	Article
Uncontrolled Keywords:	PBPK, Nanomedicine, Long&#8208, acting, Pharmacokinetics and drug metabolism, Pharmacometrics, Drug development
Depositing User:	Symplectic Admin
Date Deposited:	23 Nov 2020 11:50
Last Modified:	18 Jan 2023 23:20
DOI:	10.1002/jcph.1715
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3107943