Influence of birth weight on primary surgical management of newborns with esophageal atresia



Folaranmi, Semiu E, Jawaid, Wajid B, Gavin, Luke, Jones, Matthew O and Losty, Paul D ORCID: 0000-0003-0841-5879
(2021) Influence of birth weight on primary surgical management of newborns with esophageal atresia. JOURNAL OF PEDIATRIC SURGERY, 56 (5). pp. 929-932.

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Abstract

<h4>Background</h4>To determine if birth-weight (BW) influences primary surgical management of newborns undergoing operation for esophageal atresia and tracheo-esophageal fistula (EA-TEF).<h4>Methods</h4>Newborns undergoing repair of esophageal atresia at a single specialist centre between 1999 and 2017 were categorised into three groups based on BW; Group A < 1.5 kg, Group B <2.5 kg and Group C >2.5 kg. Outcome data analysed were (i) technical ability of the surgeon to perform primary esophageal anastomosis, (ii) anastomotic leak, (iii) anastomotic stricture, (iv) esophageal replacement, (v) need for other procedures notably fundoplication, aortopexy, tracheostomy and (vi) mortality. Statistical analysis was performed using a two-tailed Fisher's exact test and logistic regression.<h4>Results</h4>198 patients underwent surgery for EA-TEF during the study period, Group A (n = 13), Group B (n = 73) and Group C (n = 112). Inability to perform a primary anastomosis was significantly higher in Group A vs Group B (p = 0.003) and Group C (p = 0.004). Birthweight was a significant variable in the ability to perform a primary esophageal anastomosis (OR 1.009, p = 0.004). Mortality rate was significantly higher in Group A vs Group C (P = 0.0158).<h4>Conclusions</h4>Very low birth weight infants are less likely to achieve a definitive primary anastomosis during emergent repair of esophageal atresia, and have a higher mortality.

Item Type: Article
Uncontrolled Keywords: Esophageal atresia, Tracheo-esophageal fistula, Primary anastomosis, Clinical outcomes, Mortality, Birth weight
Depositing User: Symplectic Admin
Date Deposited: 11 Jan 2021 10:47
Last Modified: 18 Jan 2023 23:04
DOI: 10.1016/j.jpedsurg.2020.11.023
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3112728