Association of diet with left ventricular wall thickness, troponin I and IGF-1 in cats with subclinical hypertrophic cardiomyopathy

van Hoek, Ingrid, Hodgkiss-Geere, Hannah ORCID: 0000-0001-7561-8479, Bode, Elizabeth F ORCID: 0000-0003-3754-6026, Hamilton-Elliott, Julie, Motskula, Paul, Palermo, Valentina, Pereira, Yolanda Martinez, Culshaw, Geoff J, Laxalde, Jeremy and Dukes-McEwan, Joanna ORCID: 0000-0002-0326-8251 (2020) Association of diet with left ventricular wall thickness, troponin I and IGF-1 in cats with subclinical hypertrophic cardiomyopathy. JOURNAL OF VETERINARY INTERNAL MEDICINE, 34 (6). pp. 2197-2210.

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Official URL: http://dx.doi.org/10.1111/jvim.15925

Abstract

<h4>Background</h4>Cats with subclinical hypertrophic cardiomyopathy (sHCM) have elevated serum insulin and serum amyloid A concentrations correlating with the degree of cardiac hypertrophy. Diet might affect these and other cardiac variables.<h4>Objective</h4>Evaluate the effect of a complete, balanced diet with restricted starch and supplemented with eicosapentaenoic acid + docosahexaenoic acid (EPA + DHA) on echocardiographic variables and cardiac biomarkers in cats with sHCM.<h4>Animals</h4>Forty-four client-owned cats with sHCM.<h4>Methods</h4>A prospective, randomized, double-blind, multicenter study enrolled cats with end-diastole interventricular septum thickness (IVSd) or left ventricular wall thickness (LVWd) ≥6 mm, or both. Nonsedated, fasted cats were examined at baseline and after 6 and 12 months of Test (restricted starch and EPA + DHA supplements) (n = 23) or Control (unrestricted starch without EPA + DHA supplementation) (n = 21) diet. Assessments included auscultation, body weight, body condition score, echocardiography and blood analysis. Linear and generalized mixed models analyzed diet, time and diet * time interactions (5% significance level).<h4>Results</h4>No differences between diet groups were significant for any variable at any timepoint. There were significant decreases in the Test but not Control group in maximum IVSd (P = .03), maximum LVWd (P = .02) and insulin-like growth factor-1 levels (P = .04) after 12 months, and in ultrasensitive cardiac troponin I (cTnI) (P = .001) after 6 months; effect sizes (95% confidence interval) were 0.53 (0.09; 0.99), 0.63 (0.18; 1.09), 0.61 (0.16; 1.07), and 0.37 (-0.06; 0.8), respectively.<h4>Conclusions and clinical importance</h4>Cats with sHCM fed Test diet had significant decreases in echocardiographic variables of sHCM and in cTnI and IGF-1.

Item Type:	Article
Uncontrolled Keywords:	cardiac hypertrophy, cat, hypertrophic obstructive cardiomyopathy, insulin/IGF-1 mediated growth
Depositing User:	Symplectic Admin
Date Deposited:	12 Jan 2021 08:57
Last Modified:	18 Jan 2023 23:03
DOI:	10.1111/jvim.15925
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3113280