Albanese, Adam, Daly, Leonard A ORCID: 0000-0001-9712-9676, Mennerich, Daniela, Kietzmann, Thomas and See, Violaine ORCID: 0000-0001-6384-8381
(2021)
The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (1).
E268-.
Text
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Abstract
The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-α subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution, and their effects on HIF-dependent signalling are discussed in this review.
Item Type: | Article |
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Uncontrolled Keywords: | hypoxia, HIF-1 alpha, HIF-2 alpha, posttranslational modifications, phosphorylation, cysteine phosphorylation, methylation, acetylation, ubiquitination, sumoylation, S-nitrosylation, signalling |
Depositing User: | Symplectic Admin |
Date Deposited: | 15 Jan 2021 10:32 |
Last Modified: | 18 Jan 2023 23:03 |
DOI: | 10.3390/ijms22010268 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3113732 |