The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity



Albanese, Adam, Daly, Leonard A ORCID: 0000-0001-9712-9676, Mennerich, Daniela, Kietzmann, Thomas and See, Violaine ORCID: 0000-0001-6384-8381
(2021) The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (1). E268-.

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Abstract

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-α subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution, and their effects on HIF-dependent signalling are discussed in this review.

Item Type: Article
Uncontrolled Keywords: hypoxia, HIF-1 alpha, HIF-2 alpha, posttranslational modifications, phosphorylation, cysteine phosphorylation, methylation, acetylation, ubiquitination, sumoylation, S-nitrosylation, signalling
Depositing User: Symplectic Admin
Date Deposited: 15 Jan 2021 10:32
Last Modified: 18 Jan 2023 23:03
DOI: 10.3390/ijms22010268
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3113732