Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

Avila, Yelixza I, Chandler, Morgan, Cedrone, Edward, Newton, Hannah S, Richardson, Melina, Xu, Jie, Clogston, Jeffrey D, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Afonin, Kirill A and Dobrovolskaia, Marina A (2021) Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier. MOLECULES, 26 (3). 652-.

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Abstract

Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs' intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.

Item Type:	Article
Uncontrolled Keywords:	nucleic acid nanoparticles, NANPs, cytokines, vaccines, immunotherapies, immunology
Depositing User:	Symplectic Admin
Date Deposited:	21 Jan 2021 15:55
Last Modified:	18 Jan 2023 23:02
DOI:	10.3390/molecules26030652
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3114432