Alam, Uazman 
ORCID: 0000-0002-3190-1122, Fawwad, Asher, Shaheen, Fariha, Tahir, Bilal, Basit, Abdul and Malik, Rayaz A
(2017)
Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation.
JOURNAL OF DIABETES RESEARCH, 2017.
7928083-.
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Abstract
<h4>Objective</h4>To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy.<h4>Methods</h4>This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks.<h4>Results</h4>Of 143 participants, 41.3% were vitamin D deficient (vitamin D < 20 ng/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D (<i>P</i> < 0.0001) and a significant improvement in the NeuroQoL subscale score for emotional distress (<i>P</i> = 0.04), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of "quite a lot" (<i>P</i> < 0.05) and "very much" (<i>P</i> < 0.0001) with a significant reduction in the baseline response of having a "poor" QoL from 5.2% to 0.7% (<i>P</i> < 0.0001) and an increase in the response of an "excellent QoL" from 1.5% to 7.4% (<i>P</i> < 0.0001).<h4>Conclusion</h4>Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Pain, Peripheral Nervous System Diseases, Diabetic Neuropathies, Diabetic Foot, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Vitamin D Deficiency, 25-Hydroxyvitamin D 2, Vitamin D, Injections, Intramuscular, Severity of Illness Index, Follow-Up Studies, Stress, Psychological, Psychiatric Status Rating Scales, Cost of Illness, Quality of Life, Adult, Middle Aged, Pakistan, Female, Male, Asymptomatic Diseases |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 10 Feb 2021 11:11 |
| Last Modified: | 18 Jan 2023 23:00 |
| DOI: | 10.1155/2017/7928083 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3115433 |
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