NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes



Ponirakis, Georgios, Odriozola, Maria N, Odriozola, Samantha, Petropoulos, Ioannis N, Azmi, Shazli, Ferdousi, Maryam, Fadavi, Hassan, Alam, Uazman ORCID: 0000-0002-3190-1122, Marshall, Andrew ORCID: 0000-0001-8273-7089, Jeziorska, Maria
et al (show 7 more authors) (2016) NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 18 (12). pp. 800-805.

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Abstract

<h4>Background</h4>Accurate and economic detection of nerve damage in diabetes is key to more widespread diagnosis of patients with diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy. This study examined the diagnostic performance of NerveCheck, an inexpensive ($500) quantitative sensory testing (QST) device.<h4>Methods</h4>One hundred forty-four subjects (74 with and 70 without diabetes) underwent assessment with NerveCheck, neuropathy disability score (NDS), nerve conduction studies (NCS), intraepidermal and corneal nerve fiber density (IENFD and CNFD), and McGill questionnaire for neuropathic pain.<h4>Results</h4>Of the 74 subjects with diabetes, 41 were diagnosed with DPN based on the NDS. The NerveCheck scores for vibration perception threshold (VPT), cold perception threshold (CPT), and warm perception threshold (WPT) were significantly lower (P ≤ 0.0001) in diabetic patients with DPN compared to patients without DPN. The diagnostic accuracy of VPT was high with reference to NCS (area under the curve [AUC]: 82%-84%) and moderate for IENFD, CNFD, and neuropathic pain (AUC: 60%-76%). The diagnostic accuracy of CPT and WPT was moderate with reference to NCS, IENFD, and CNFD (AUC: 69%-78%) and low for neuropathic pain (AUC: 63%-65%).<h4>Conclusions</h4>NerveCheck is a low-cost QST device with good diagnostic utility for identifying sensory deficits, comparable to established tests of large and small fiber neuropathy and for the severity of neuropathic pain.

Item Type: Article
Uncontrolled Keywords: NerveCheck, Quantitative sensory testing, Diabetic peripheral neuropathy, Diagnostic device
Depositing User: Symplectic Admin
Date Deposited: 10 Feb 2021 11:26
Last Modified: 18 Jan 2023 23:00
DOI: 10.1089/dia.2016.0279
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3115439