The Role of Raman Spectroscopy Within Quantitative Metabolomics

Lima, Cassio, Muhamadali, Howbeer and Goodacre, Royston ORCID: 0000-0003-2230-645X (2021) The Role of Raman Spectroscopy Within Quantitative Metabolomics. Annual Review of Analytical Chemistry, 14 (1). pp. 323-345.

Text PDF file of the entire manuscript, including all figures and tables.pdf - Author Accepted Manuscript Download (1MB) | Preview

Abstract

<jats:p> Ninety-two years have passed since the discovery of the Raman effect, and there are currently more than 25 different types of Raman-based techniques. The past two decades have witnessed the blossoming of Raman spectroscopy as a powerful physicochemical technique with broad applications within the life sciences. In this review, we critique the use of Raman spectroscopy as a tool for quantitative metabolomics. We overview recent developments of Raman spectroscopy for identification and quantification of disease biomarkers in liquid biopsy, with a focus on the recent advances within surface-enhanced Raman scattering–based methods. Ultimately, we discuss the applications of imaging modalities based on Raman scattering as label-free methods to study the abundance and distribution of biomolecules in cells and tissues, including mammalian, algal, and bacterial cells. </jats:p><jats:p> Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 14 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. </jats:p>

Item Type:	Article
Uncontrolled Keywords:	Raman spectroscopy, metabolomics, surface-enhanced Raman scattering, SERS, coherent anti-Stokes Raman spectroscopy, CARS, stimulated Raman spectroscopy, SRS, spatially offset Raman spectroscopy, SORS
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	19 Apr 2021 09:59
Last Modified:	06 Mar 2023 11:30
DOI:	10.1146/annurev-anchem-091420-092323
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3119678