Asproni, Pietro, Millanta, Francesca, Ressel, Lorenzo 
ORCID: 0000-0002-6614-1223, Podesta, Fabio, Parisi, Francesca, Vannozzi, Iacopo and Poli, Alessandro
(2021)
An Immunohistochemical Study of the PTEN/AKT Pathway Involvement in Canine and Feline Mammary Tumors.
ANIMALS, 11 (2).
365-.
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An Immunohistochemical Study of the PTENAKT Pathway Involvement in Canine and Feline Mammary Tumors.pdf - Published version Download (2MB) | Preview |
Abstract
Phosphatase and tensin homolog deleted on chromosome10 (PTEN), phospho-v-Akt murine thymoma viral oncogene homolog (AKT), and the Rapamycin-Insensitive Companion of mTOR (Rictor) expression was investigated by immunohistochemistry in 10 canine mammary adenomas (CMAs), 40 canine mammary carcinomas (CMCs), and 30 feline mammary carcinomas (FMCs). All the CMAs, 25 of 40 CMCs (63%) and 7 of 30 FMCs (23%), were PTEN-positive. In dogs, no CMAs and 15 of 25 CMCs (37%) expressed phospho-AKT (p-AKT), while 24 of 30 FMCs (82%) were p-AKT-positive. One of 10 CMAs (10%), 24 of 40 CMCs (60%) and 20 of 30 FMCs (67%) were Rictor-positive. In the dog, PTEN expression correlated with less aggressive tumors, absence of lymphatic invasion, and longer survival. P-AKT expression correlated with more aggressive subtype, lymphatic invasion, and poorer survival and Rictor expression with lymphatic invasion. In cats, PTEN correlated with less aggressive carcinomas, absence of lymphatic invasion, and better survival. P-AKT and Rictor expression correlated with poorer survival. PTEN expression was inversely correlated with p-AKT and Rictor in both species, while p-AKT positively correlated with Rictor expression. A strong PTEN/AKT pathway involvement in behavior worsening of CMT and FMTs is demonstrated, providing a rationale for further studies of this pathway in veterinary oncology.
| Item Type: | Article |
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| Uncontrolled Keywords: | cat, dog, immunohistochemistry, mammary tumors, phospho-AKT, PTEN, Rictor |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 May 2021 13:04 |
| Last Modified: | 18 Jan 2023 22:47 |
| DOI: | 10.3390/ani11020365 |
| Open Access URL: | https://www.mdpi.com/2076-2615/11/2/365 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3122701 |
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