Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double-blind, multicentre, randomized, placebo-controlled study



Noli, Chiara, della Valle, Maria Federica, Miolo, Alda, Medori, Cristina, Schievano, Carlo, Balletti, Erika, Beccati, Massimo, Bomben, Luigi, Cerqua, Antonietta, Colombo, Silvia
et al (show 36 more authors) (2019) Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double-blind, multicentre, randomized, placebo-controlled study. VETERINARY DERMATOLOGY, 30 (5). 387-+.

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Abstract

<h4>Background</h4>Feline nonflea hypersensitivity dermatitis (NFHD) is a frequent cause of over-grooming, scratching and skin lesions. Multimodal therapy often is necessary.<h4>Hypothesis/objectives</h4>To investigate the efficacy of ultramicronized palmitoylethanolamide (PEA-um) in maintaining methylprednisolone-induced remission in NFHD cats.<h4>Animals</h4>Fifty-seven NFHD cats with nonseasonal pruritus were enrolled originally, of which 25 completed all study requirements to be eligible for analysis.<h4>Methods and materials</h4>Cats were randomly assigned to PEA-um (15 mg/kg per os, once daily; n = 29) or placebo (n = 28) while receiving a 28 day tapering methylprednisolone course. Cats responding favourably to methylprednisolone were then administered only PEA-um (n = 21) or placebo (n = 23) for another eight weeks, followed by a four week long treatment-free period. Cats were maintained in the study until relapse or study end, whichever came first. Primary outcome was time to relapse. Secondary outcomes were pruritus Visual Analog Scale (pVAS), SCORing Feline Allergic Dermatitis scale (SCORFAD) and owner Global Assessment Score (GAS).<h4>Results</h4>Mean relapse time was 40.5 days (±7.8 SE) in PEA-um treated cats (n = 13) and 22.2 days (±3.7 SE) for placebo (n = 12; P = 0.04). On Day 28, the severity of pruritus was lower in the PEA-um treated cats compared to placebo (P = 0.03). Mean worsening of pruritus at the final study day was lower in the PEA-um group compared to placebo (P = 0.04), whereas SCORFAD was not different between groups. Mean owner GAS at the final study day was better in the PEA-um than the placebo-treated group (P = 0.05).<h4>Conclusion and clinical importance</h4>Ultramicronized palmitoylethanolamide could represent an effective and safe option to delay relapse in NFHD cats.

Item Type: Article
Uncontrolled Keywords: Skinalia Clinical Research Group, Animals, Cats, Dermatitis, Allergic Contact, Cat Diseases, Ethanolamines, Amides, Palmitic Acids, Anti-Inflammatory Agents, Non-Steroidal, Dietary Supplements
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 20 May 2021 10:20
Last Modified: 18 Jan 2023 22:46
DOI: 10.1111/vde.12764
Open Access URL: https://doi.org/10.1111/vde.12764
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3123413