A SYSTEMATIC REVIEW OF URINE BIOMARKERS IN CHILDREN WITH IGA VASCULITIS NEPHRITIS.

Williams, Chloe ORCID: 0000-0002-9276-0255, Toner, Aileen, Wright, Rachael D ORCID: 0000-0002-7606-2297 and Oni, Louise ORCID: 0000-0002-1532-2390 (2021) A SYSTEMATIC REVIEW OF URINE BIOMARKERS IN CHILDREN WITH IGA VASCULITIS NEPHRITIS. PEDIATRIC NEPHROLOGY, 36 (10). p. 3376.

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Official URL: http://dx.doi.org/10.1007/s00467-021-05107-7

Abstract

<h4>Background</h4>Nephritis is a recognised complication of IgA vasculitis (IgAV, Henoch-Schönlein purpura) contributing to 1-2% of all chronic kidney disease (CKD) stage 5. Improved understanding may reduce irreversible damage in IgAV nephritis (IgAV-N).<h4>Objective</h4>The aim of this study was to perform a comprehensive systematic literature review to identify promising clinical and pre-clinical urine biomarkers in children with IgAV-N that could predict the presence of nephritis and/or determine its severity.<h4>Methods</h4>A systematic literature review was performed using four search engines and a predefined search term strategy. Promising biomarkers were divided in terms of clinical or pre-clinical and ability to predict the presence of nephritis or determine its severity. Results were described using statistical significance (p < 0.05) and area under the curve (AUC) values.<h4>Results</h4>One hundred twenty-one studies were identified; 13 were eligible. A total of 2446 paediatric patients were included: healthy controls (n = 761), children with IgAV-N (n = 1236) and children with IgAV without nephritis (IgAV-noN, n = 449). Fifty-one percent were male, median age 7.9 years. The clinical markers, 24-h protein quantity and urine protein:creatinine ratio, were deemed acceptable for assessing severity of nephritis (AUC < 0.8). Urinary albumin concentration (Malb) performed well (AUC 0.81-0.98). The most promising pre-clinical urinary biomarkers in predicting presence of nephritis were as follows: kidney injury molecule-1 (KIM-1) (AUC 0.93), monocyte chemotactic protein-1 (MCP-1) (AUC 0.83), N-acetyl-β-glucosaminidase (NAG) (0.76-0.96), and angiotensinogen (AGT) (AUC not available). Urinary KIM-1, MCP-1, and NAG appeared to correlate with disease severity.<h4>Conclusions</h4>Longitudinal studies are needed to assess whether pre-clinical biomarkers enhance standard of care in IgAV-N.

Item Type:	Article
Uncontrolled Keywords:	IgA vasculitis, Henoch-Sch&#246, nlein purpura, Nephritis, Children, Urine, Biomarker
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	09 Jun 2021 11:15
Last Modified:	18 Jan 2023 22:35
DOI:	10.1007/s00467-021-05107-7
Open Access URL:	http://doi.org/10.1007/s00467-021-05107-7
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3125729