Post-Transplantation Diabetes Mellitus

Ahmed, Syed Hans ORCID: 0000-0002-7815-2907, Biddle, Kathryn, Augustine, Titus and Azmi, Shazli (2020) Post-Transplantation Diabetes Mellitus. DIABETES THERAPY, 11 (4). pp. 779-801.

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Official URL: http://dx.doi.org/10.1007/s13300-020-00790-5

Abstract

Solid organ transplantation (SOT) is an established therapeutic option for chronic disease resulting from end-stage organ dysfunction. Long-term use of immunosuppression is associated with post-transplantation diabetes mellitus (PTDM), placing patients at increased risk of infections, cardiovascular disease and mortality. The incidence rates for PTDM have varied from 10 to 40% between different studies. Diagnostic criteria have evolved over the years, as a greater understating of PTDM has been reached. There are differences in pathophysiology and clinical course of type 2 diabetes and PTDM. Hence, managing this condition can be a challenge for a diabetes physician, as there are several factors to consider when tailoring therapy for post-transplant patients to achieve better glycaemic as well as long-term transplant outcomes. This article is a detailed review of PTDM, examining the pathogenesis, diagnostic criteria and management in light of the current evidence. The therapeutic options are discussed in the context of their safety and potential drug-drug interactions with immunosuppressive agents.

Item Type:	Article
Uncontrolled Keywords:	Calcineurin inhibitors, Diabetes mellitus, Graft failure, Macrovascular, Microvascular, Mortality, mTOR inhibitors, Post-transplantation, Rejection, Steroids
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine
Depositing User:	Symplectic Admin
Date Deposited:	06 Jul 2021 10:06
Last Modified:	18 Jan 2023 21:36
DOI:	10.1007/s13300-020-00790-5
Open Access URL:	https://doi.org/10.1007/s13300-020-00790-5
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3128995