Health-related quality of life and utility outcomes with selinexor in relapsed/refractory diffuse large B-cell lymphoma



Shah, Jatin, Shacham, Sharon, Kauffman, Michael, Daniele, Patrick, Tomaras, Dimitrios, Tremblay, Gabriel, Casasnovas, Rene-Olivier, Maerevoet, Marie, Zijlstra, Josee, Follows, George
et al (show 26 more authors) (2021) Health-related quality of life and utility outcomes with selinexor in relapsed/refractory diffuse large B-cell lymphoma. FUTURE ONCOLOGY, 17 (11). pp. 1295-1310.

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Abstract

<b>Aim:</b> Evaluate health-related quality of life (HRQoL) and health utility impact of single-agent selinexor in heavily pretreated patients with relapsed/refractory diffuse large B-cell lymphoma. <b>Patients & methods:</b> Functional Assessment of Cancer Therapy (FACT) - Lymphoma and EuroQoL five-dimensions five-levels data collected in the single-arm Phase IIb trial SADAL (NCT02227251) were analyzed with mixed-effects models. <b>Results:</b> Treatment responders maintained higher FACT - Lymphoma (p ≤ 0.05), FACT - General (p < 0.05) and EuroQoL five-dimensions five-levels index scores (p < 0.001) beginning in cycle 3. The estimated difference in health state utilities for treatment response and progressive disease was both statistically significant and clinically meaningful (mean difference: 0.07; p = 0.001). <b>Conclusion:</b> In patients with relapsed/refractory diffuse large B-cell lymphoma, objective response to selinexor was associated with HRQoL maintenance, reduction in disease-related HRQoL decrements and higher health utilities.

Item Type: Article
Uncontrolled Keywords: diffuse large B-cell lymphoma, disutility of adverse events, EQ-5D-5L, FACT-Lym, health-related quality of life, health state utility, health utility, patient reported outcomes, selinexor
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 07 Jul 2021 10:13
Last Modified: 20 May 2024 10:49
DOI: 10.2217/fon-2020-0946
Open Access URL: https://doi.org/10.2217/fon-2020-0946
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3129125