Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Relapse With COVID-19

Woodhall, Mark, Mitchell, James W ORCID: 0000-0002-6465-0382, Gibbons, Emily, Healy, Sarah, Waters, Patrick and Huda, Saif (2020) Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Relapse With COVID-19. FRONTIERS IN NEUROLOGY, 11. 598531-.

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Abstract

A 39-year-old lady with relapsing myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease developed coryzal symptoms, malaise, sweating, and postural dizziness. Six days later she presented with painful progressive right visual loss consistent with optic neuritis. COVID-19 was confirmed by nasopharyngeal swab and MOG-IgG serological reversion was noted. Visual function improved following steroids and plasma exchange. This case highlights a possible causal association between inflammation due to COVID-19 and a relapse of MOG-IgG associated disease. It also highlights the clinical relevance of reporting MOG-IgG titers in MOG-IgG associated disease.

Item Type:	Article
Uncontrolled Keywords:	myelin-oligodendrocyte glycoprotein (MOG), optic neuritis, Devic&apos, s disease, visual loss, post-infectious, autoimmune diseases
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	09 Jul 2021 08:40
Last Modified:	18 Jan 2023 21:36
DOI:	10.3389/fneur.2020.598531
Open Access URL:	http://doi.org/10.3389/fneur.2020.598531
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3129400