Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa



Morton, Ben ORCID: 0000-0002-6164-2854, Barnes, Kayla G, Anscombe, Catherine, Jere, Khuzwayo ORCID: 0000-0003-3376-8529, Matambo, Prisca, Mandolo, Jonathan, Kamng'ona, Raphael, Brown, Comfort, Nyirenda, James, Phiri, Tamara
et al (show 15 more authors) (2021) Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa. NATURE COMMUNICATIONS, 12 (1). 3554-.

[img] Text
Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa.pdf - Published version

Download (4MB) | Preview

Abstract

Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.

Item Type: Article
Uncontrolled Keywords: Blantyre COVID-19 Consortium, Humans, Dexamethasone, Immunoglobulin G, Immunoglobulin M, Antibodies, Cytokines, Anti-Bacterial Agents, Adult, Middle Aged, Africa South of the Sahara, Female, Male, Pandemics, Coinfection, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 11 Aug 2021 08:22
Last Modified: 09 Feb 2023 10:28
DOI: 10.1038/s41467-021-23267-w
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3133064