The Sabadell score is an independent predictor of five-year outcome after critical care discharge

Morton, Ben ORCID: 0000-0002-6164-2854, Penston, Victoria, McHale, Phillip, Hungerford, Daniel ORCID: 0000-0002-9770-0163 and Dempsey, Ged (2019) The Sabadell score is an independent predictor of five-year outcome after critical care discharge. [Preprint]

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Official URL: http://dx.doi.org/10.21203/rs.2.19576/v1

Abstract

<h4>Background: </h4> Critical care survivors frequently suffer persistent morbidity and increased risk of mortality compared to the general population. However, there are no standardised tools to identify at-risk patients to target potential interventions. Our aim was to establish whether the “Sabadell score”, a simple tool applied upon critical care discharge, is an independent predictor of five-year mortality. <h4>Methods:</h4> Prospective observational cohort study of adults admitted to a mixed critical care unit at Aintree University Hospital NHS Foundation Trust, Liverpool, United Kingdom. Sabadell score applied to all patients from September 2011 to December 2017. Primary outcome: five-year mortality assessed using a multivariable flexible parametric survival analysis adjusted for demographics, and clinically relevant covariates. Primary outcome: Adults discharged alive following critical care admission. <h4>Results:</h4> There were 5954 patients with a minimum of 18 months follow-up. Mean age was 59.5 (SD±17) and 57.1% were male. Patients were categorised into Sabadell scores, zero (38.4%), one (47.9%), two (10.5%) and three (3.1%). Adjusted hazard ratios for mortality were 2.09 (C.I. 1.85–2.36), 3.95 (C.I. 3.39–4.60) and 21.04 (C.I. 17.24–25.68) respectively. Sabadell score three predicted 99.9%, 99.5%, 98.5% and 87.4% mortality at five years for patients ³80 (aHR 3.37), 60-79 (aHR 2.52), 40-59 (aHR 2.03) and 16-39 respectively. A Sabadell score of two predicted 71.0%, 52.7%, 44.8% and 23.7% mortality at five years for these age categories.Conclusions : Sabadell score is an independent predictor of five-year survival after critical care discharge. These findings could be used to guide provision of increased support for patients after critical care discharge and/or informed discussions with patients and relatives about dying to ascertain their future wishes.

Item Type:	Preprint
Uncontrolled Keywords:	Clinical Research, 3 Good Health and Well Being
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	26 Aug 2021 07:47
Last Modified:	14 Mar 2024 22:20
DOI:	10.21203/rs.2.19576/v1
Open Access URL:	https://www.researchsquare.com/article/rs-10189/v1
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3134805